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Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 516-520 doi: 10.1007/s11705-017-1658-7

Abstract: In order to assure the safety and efficacy of pharmaceutical products, we need an predictive tool forIf the 20th century was the ‘age of the drug’, i.e., the ‘magic bullet’, the 21st century must becomethe ‘age of the guided missile’, i.e., the delivery system, including the form of the active pharmaceuticalIn this article, we present the predicted drug dissolution profile of ketoconazole as a model drugThis dissolution system allows the monitoring of the drug dissolution phenomena and the observation of

Keywords： GIS     <i>in vivoi> predictive dissolution     ketoconazole     BCS subclassification     supersaturation    

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Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 195-203 doi: 10.1007/s11684-012-0189-3

Abstract:

The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofenThe dissolution of ibuprofen in urea was higher than in PEG4000 or mannitol.SDs were characterized in terms of dissolution, differential scanning calorimetry (DSC), X-ray diffraction In vitro release results indicated that the ibuprofen dissolution rate was improved by theThe dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea

Keywords： ibuprofen     solid dispersion     physical mixture     dissolution     anti-inflammatory effect    

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Research progress on hydrothermal dissolution and hydrolysis of lignocellulose and lignocellulosic waste

Yan ZHAO, Wenjing LU, Jiajun CHEN, Xiangfeng ZHANG, Hongtao WANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 151-161 doi: 10.1007/s11783-013-0607-z

Abstract: inadequate information on the conversion mechanisms of lignocellulose, particularly the reaction rules of dissolutionThis paper critically reviewed the progress done in the research and development of the hydrothermal dissolutionPrinciples, processes, and related studies on separate dissolution and asynchronous hydrolysis of lignin

Keywords： lignocellulosic waste     hydrothermal conversion     separate dissolution     asynchronous hydrolysis     mechanism    

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Cadmium removal mechanistic comparison of three Fe-based nanomaterials: Water-chemistry and roles of Fe dissolution

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 12, doi: 10.1007/s11783-022-1586-8

Abstract:

● nZVI, S-nZVI, and nFeS were systematically compared for Cd(II) removal.

Keywords： Nano zero valent iron     Sulfided zero valent iron     FeS     Cd(II) immobilization     Fe dissolution    

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Effects of rotor and stator geometry on dissolution process and power consumption in jet-flow high shear

Lin Yang, Wenpeng Li, Junheng Guo, Wei Li, Baoguo Wang, Minqing Zhang, Jinli Zhang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2,   Pages 384-398 doi: 10.1007/s11705-020-1928-7

Abstract: The jet-flow high shear mixer (JF-HSM) is a new type of intensified equipment with special configurations of the rotor and the stator. The mass transfer property and power consumption were studied in the solid-liquid system for a series of JF-HSMs involving different configuration parameters, such as rotor diameter, rotor blade inclination, rotor blade bending direction, stator diameter, and stator bottom opening diameter. The flow characteristics were examined by computational fluid dynamic simulations. Results indicate that the turbulent power consumption of the JF-HSM is affected by the change in rotor blade inclination and stator bottom opening. With the increase in the shear head size and the change in the rotor into a backward-curved blade, the solid-liquid mass transfer rate can be remarkably increased under the same input power. Dimensionless correlations for the mass transfer coefficient and power consumption were obtained to guide the scale-up design and selection of such a new type of equipment to intensify the overall mixing efficiency.

Keywords： jet-flow high shear mixer     solid particle dissolution     power consumption characteristics     CFD Simulation    

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Dynamic Power Management for I/O Devices Under Multi-task Environment

Qi Longning,Zhang Zhe,Huang Shaomin

Strategic Study of CAE 2008, Volume 10, Issue 2,   Pages 60-65

Abstract: : justify;">More embedded system designers pay attention to how to reduce the po wer consumption of I/The paper presents a stack-based predictive timeout strategy (SBPT).It c an predict the access pattern of the device I/O operations by analyzing the ca lling and stack informationAt last, classify the I/O request by the global prediction and then make the de cision with the timeout

Keywords： DPM     predictive timeout     stack     multiple service requesters    

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Real-time mobile robot teleoperation via Internet based on predictive control

WANG Shihua, XU Bugong, WANG Shihua, ZHOU Yeming, LIU YunHui

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3,   Pages 299-306 doi: 10.1007/s11465-008-0049-7

Abstract: To compensate for the network delay and counteract its impact on the teleoperation system, a predictiveForce feedback and a virtual predictive display are introduced to enhance the real-time efficiency of

Keywords： predictive     feedback     virtual predictive     distance     synchronization algorithm    

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Multi-timescale optimization scheduling of interconnected data centers based on model predictive control

Frontiers in Energy doi: 10.1007/s11708-023-0912-6

Abstract: multi-timescale optimal scheduling model is established for interconnected data centers (IDCs) based on model predictive

Keywords： model predictive control     interconnected data center     multi-timescale     optimized scheduling     distributed    

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The CatMath: an online predictive platform for thermal + electrocatalysis

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 2156-2160 doi: 10.1007/s11705-023-2371-3

Abstract: The catalytic volcano activity models are the quantified and visualized tools of the <i>Sabatieri>intrinsic activity optima and trends of a catalytic reaction as a function of the reaction descriptors, i.e

Keywords： CatMath     catalysis     volcano activity plots     Surface Pourbaix Diagrams     online platform    

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Extended model predictive control scheme for smooth path following of autonomous vehicles

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 1,   Pages 4-4 doi: 10.1007/s11465-021-0660-4

Abstract: This paper presents an extended model predictive control (MPC) scheme for implementing optimal path following

Keywords： autonomous vehicles     vehicle dynamic modeling     model predictive control     path following     optimization    

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machine-learning-based system identification of dynamical systems under control: application towards the model predictive

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 237-250 doi: 10.1007/s11705-021-2058-6

Abstract: ., model predictive control, can offer superior control of key process variables for multiple-input multiple-outputblack-box nonlinear continuous-time multiple-input multiple-output system models for nonlinear model predictiveoutput and manipulated variables were trained on simulated data and integrated into a nonlinear model predictiveThis demonstration of how such system models could be identified for nonlinear model predictive control

Keywords： nonlinear model predictive control     black-box modeling     continuous-time system identification     machine    

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Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 32-44 doi: 10.1007/s11684-018-0678-0

Abstract: Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to

Keywords： immune checkpoint     companion diagnosis     PD-L1     tumor mutation burden     immune score    

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Crystal modification of rifapentine using different solvents

Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 65-69 doi: 10.1007/s11705-009-0302-6

Abstract: The comparative dissolution behaviors of the newly developed crystals and of rifapentine without beingThe dissolution rate of newly developed crystals was found to be higher than that of rifapentine withoutHowever, the modified crystal obtained from acetic acid shows the lower dissolution rate than crystals

Keywords： identical     scanning calorimetry     different     comparative dissolution     structure modification    

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Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic

XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 316-319 doi: 10.1007/s11684-007-0061-z

Abstract: The aim of this study was to observe the changes in glucose metabolism after antipsychotic (APS) therapy, to note the influencing factors, as well as to discuss the relationship between the occurrence of glucose metabolism disorders of APS origin and abnormal glycosylated hemoglobin (HbAc) levels. One hundred and fifty-two patients with schizophrenia, whose fasting plasma glucose (FPG) and 2-h plasma glucose (2hPG) in the oral glucose tolerance test (2HPG) were normal, were grouped according to the HbAc levels, one normal and the other abnormal, and were randomly enrolled into risperidone, clozapine and chlorpromazine treatment for six weeks. The FPG and 2hPG were measured at the baseline and at the end of the study. In the group with abnormal HbA1c and clozapine therapy, 2HPG was higher after the study [(9.5±1.8) mmol/L] than that before the study [(7.2±1.4) mmol/L] and the difference was statistically significant (〈0.01). FPG had no statistically significant difference before and after the study in any group (〉0.05). HbAc levels and drugs contributing to 2HPG at the end of study had statistical cross-action (〈0.01). In the abnormal HbAc group, 2HPG after the study was higher in the clozapine treatment group [(9.5±1.8) mmol/L] than in the risperidone treatment group [(7.4±1.7) mmol/L] and the chlorpromazine treatment group [(7.3±1.6) mmol/L]. The differences were statistically significant (〈0.01). In the normal HbAc group there was no statistically significant difference before and after the study in any group (〉0.05). 2HPG before [(7.1±1.6) mmol/L] and after the study [(8.1±1.9) mmol/L] was higher in the abnormal HbAc group than in the normal HbAc group [(6.2±1.4) mmol/L (6.5±1.4) mmol/L] with the difference being statistically significant (〈0.01 〈0.001). As compared with normal HbAc group, the relative risk (RR) of glucose metabolism disease occurrence was 4.7 in the abnormal HbAc group with the difference being statistically significant (〈0.001). Patients with abnormal HbAc are more likely to have a higher risk of having glucose metabolism disorders after APS treatment.

Keywords： significant difference     occurrence     hemoglobin     risperidone treatment     abnormal    

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Modeling of specific structure crystallization coupling with dissolution

Yuanhui JI, Hongliang QIAN, Chang LIU, Xiaohua LU, Xin FENG, Xiaoyan JI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 52-56 doi: 10.1007/s11705-009-0301-7

Abstract: coefficient model of the solution, the second is Solid-Liquid equilibrium, the third and fourth are the dissolutionmechanisms of complex structure formation and microphase transition can be analyzed by combining the dissolution

Keywords： structure crystallization     activity coefficient     reference     KCl     dissolution    

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Title Author Date Type Operation

Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Journal Article

Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Journal Article

Research progress on hydrothermal dissolution and hydrolysis of lignocellulose and lignocellulosic waste

Yan ZHAO, Wenjing LU, Jiajun CHEN, Xiangfeng ZHANG, Hongtao WANG

Journal Article

Cadmium removal mechanistic comparison of three Fe-based nanomaterials: Water-chemistry and roles of Fe dissolution

Journal Article

Effects of rotor and stator geometry on dissolution process and power consumption in jet-flow high shear

Lin Yang, Wenpeng Li, Junheng Guo, Wei Li, Baoguo Wang, Minqing Zhang, Jinli Zhang

Journal Article

Dynamic Power Management for I/O Devices Under Multi-task Environment

Qi Longning,Zhang Zhe,Huang Shaomin

Journal Article

Real-time mobile robot teleoperation via Internet based on predictive control

WANG Shihua, XU Bugong, WANG Shihua, ZHOU Yeming, LIU YunHui

Journal Article

Multi-timescale optimization scheduling of interconnected data centers based on model predictive control

Journal Article

The CatMath: an online predictive platform for thermal + electrocatalysis

Journal Article

Extended model predictive control scheme for smooth path following of autonomous vehicles

Journal Article

machine-learning-based system identification of dynamical systems under control: application towards the model predictive

Journal Article

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Journal Article

Crystal modification of rifapentine using different solvents

Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,

Journal Article

Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic

XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian

Journal Article

Modeling of specific structure crystallization coupling with dissolution

Yuanhui JI, Hongliang QIAN, Chang LIU, Xiaohua LU, Xin FENG, Xiaoyan JI,

Journal Article